GLYCINE B ANTAGONISTS

The invention relates to 4-aminonaphthalene-2-carboxylic acids and 1-amino- isoquinoline-3-carboxylic acids as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists a...

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Main Authors PISKUNOVA, IRENA, WOLTER, FALKO ERNST, KRUEGER, BJOERN, ROZHKOVS, JEVGENIJS, KAUSS, VALERJANS, HANSEN, ANGELA, GRUNSTEINE, GINTA, TRIFANOVA, DINA, TURE, ANASTASIJA, ZVAGULIS, ARTIS, ABEL, ULRICH
Format Patent
LanguageEnglish
French
Published 07.03.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to 4-aminonaphthalene-2-carboxylic acids and 1-amino- isoquinoline-3-carboxylic acids as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders. L'invention concerne des acides 4-aminonaphtalène-2-carboxylique et des acides 1-amino-isoquinoline-3-carboxyliques, ainsi que leurs sels pharmaceutiquement acceptables. L'invention concerne également un procédé de préparation de tels composés. Les composés de l'invention sont des antagonistes de glycine B et sont par conséquent utiles pour le contrôle et la prévention de divers troubles, y compris les troubles neurologiques.
Bibliography:Application Number: WO2012EP66999