FUSED TRICYCLIC COMPOUNDS AS mTOR INHIBITORS

• Main Authors: SIDDIQUI, M. ARSHAD, PATEL, MEHUL, F, MENG, ZHAOYANG, REDDY, PANDURANGA ADULLA, P, NAN, YANG
• Format: Patent
• Language: English; French
• Published: 31.01.2013
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention relates to certain pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine and dipyrazolopyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine or dipyrazolopyrimidine compounds. La présente invention concerne certains composés pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidines et dipyrazolopyrimidines de Formule (I) en tant qu'inhibiteurs de la kinase mTOR (cible de la rapamycine chez les mammifères), qui est également connue comme FRAP, RAFT, RAPT ou SEP. Les composés peuvent être utilisés dans le traitement du cancer et autres troubles où la mTOR est dérégulés. La présente invention concerne également des compositions pharmaceutiques comprenant les composés pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidines ou dipyrazolopyrimidines.