NOVEL IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS mTOR INHIBITORS

The present invention relates to certain Imidazopyrazine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The pres...

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Bibliographic Details
Main Authors SIDDIQUI, M. ARSHAD, MENG, ZHAOYANG, REDDY, PANDURANGA ADULLA, P
Format Patent
LanguageEnglish
French
Published 31.01.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to certain Imidazopyrazine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the Imidazopyrazine compounds. La présente invention concerne certains composés de type imidazopyrazine de formule (I) pouvant être utilisés en tant qu'inhibiteurs de la kinase cible de la rapamycine chez les mammifères (mTOR), qui est également connue sous le nom de FRAP, RAFT, RAPT ou SEP. Lesdits composés peuvent être utilisés dans le cadre du traitement du cancer et d'autres affections impliquant un dérèglement de mTOR. La présente invention concerne, en outre, des compositions pharmaceutiques contenant lesdits composés de type imidazopyrazine.
Bibliography:Application Number: WO2012US47522