PROCESS FOR PREPARATION OF DRONEDARONE USING AMIDE INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that the compound of formula (II) is reduced, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt...

Full description

Saved in:
Bibliographic Details
Main Authors HUSZAR, CSABA, CSATARINE NAGY, MARIANNA, DOMBRADY, ZSOLT, FRIESZ, ANTAL
Format Patent
LanguageEnglish
French
Published 31.01.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that the compound of formula (II) is reduced, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof. La présente invention concerne un nouveau procédé de préparation de dronédarone de formule (I) et de ses sels pharmaceutiquement acceptables. L'invention est caractérisée en ce qu'un composé de formule (II) est réduit, et que le produit obtenu est isolé et, si on le souhaite, converti en un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également de nouveaux composés intermédiaires et leur préparation.
Bibliography:Application Number: WO2012HU00065