REDUCTIVE ANIMATION PROCESS FOR PREPARATION OF DRONEDARONE USING ALDEHYDE INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that the compound of formula (II) is reacted with dibutylamine of formula (III), under reducing circumstances, and the obtained product is isolated a...

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Bibliographic Details
Main Authors DOMBRADY, ZSOLT, FRIESZ, ANTAL
Format Patent
LanguageEnglish
French
Published 31.01.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that the compound of formula (II) is reacted with dibutylamine of formula (III), under reducing circumstances, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof, The invention also relates to some novel intermediary compounds and the preparation thereof. La présente invention concerne un nouveau procédé de préparation de dronédarone de formule (I) et de ses sels pharmaceutiquement acceptables. Ce procédé est caractérisé en ce qu'un composé de formule (II) est mis à réagir avec de la dibutylamine de formule (III) dans des conditions réductrices, et que le produit obtenu est isolé et, si on le souhaite, converti en un sel pharmaceutiquement acceptable de ce dernier. L'invention concerne également de nouveaux composés intermédiaires et leur préparation.
Bibliography:Application Number: WO2012HU00064