REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING CARBOXYL INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof : Formula (I) characterized in that a compound of formula (II) : Formula (II) is aminated with compound of formula (III) among reductive conditions, : Formula (III) an...

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Bibliographic Details
Main Authors DOMBRADY, ZSOLT, FRIESZ, ANTAL
Format Patent
LanguageEnglish
French
Published 31.01.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof : Formula (I) characterized in that a compound of formula (II) : Formula (II) is aminated with compound of formula (III) among reductive conditions, : Formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof. La présente invention concerne un nouveau procédé de préparation de dronédarone de formule (I) et de ses sels pharmaceutiquement acceptables. Ce procédé est caractérisé en ce qu'un composé de formule (II) subit une amination avec un composé de formule (III) dans des conditions réductrices: et que le produit obtenu est isolé et, si on le souhaite, converti en un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également de nouveaux composés intermédiaires et leur préparation.
Bibliography:Application Number: WO2012HU00063