PRAME PURIFICATION

The present invention relates to methods for the purification of PRAME. In particular the present invention relates to a method for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contempor...

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Main Authors LAANAN, AMINA, DODE, LEONARD, LEMOINE, DOMINIQUE, INGRID, GODART, STEPHANE, ANDRE, LE BUSSY, OLIVIER, PATRICK, HARVENGT, POL, GUY, GERMAY, OLIVIER, C
Format Patent
LanguageEnglish
French
Published 31.01.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to methods for the purification of PRAME. In particular the present invention relates to a method for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange; and (ii) exchanging protein from diluent A to diluent B. Compositions produced by the method are also provided. La présente invention concerne des procédés de purification de PRAME. En particulier, la présente invention concerne un procédé de réduction de l'agrégation de PRAME au cours d'un échange de diluant à partir d'un diluant A à un diluant B, consistant à : (i) ajouter un composé polyanionique d'un diluant A avant ou simultanément à l'échange; et (ii) échanger une protéine à partir d'un diluant A à un diluant B. L'invention concerne également des compositions produites par le procédé.
Bibliography:Application Number: WO2012EP64340