MODIFIED PLATINUM COMPOUNDS

The present invention relates to platinum compounds, modified by conjugation with thiol-containing moieties, such as cysteine or N-acetyl cystein (NAC), and to pharmaceutical compositions comprising said modified platinum compounds. The invention further provides methods for treatment of a malignanc...

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Bibliographic Details
Main Author AYOUB, AMAL
Format Patent
LanguageEnglish
French
Published 24.01.2013
Subjects
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
RADIATION THERAPY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
ULTRASOUND THERAPY
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Summary:The present invention relates to platinum compounds, modified by conjugation with thiol-containing moieties, such as cysteine or N-acetyl cystein (NAC), and to pharmaceutical compositions comprising said modified platinum compounds. The invention further provides methods for treatment of a malignancy comprising administering said modified platinum compounds and their activation. La présente invention concerne des composés de platine, modifiés par conjugaison avec des fragments contenant thiol, tels que la cystéine ou N-acétylcystéine (NAC), et des compositions pharmaceutiques comprenant lesdits composés de platine modifiés. L'invention concerne en outre des procédés pour le traitement d'une malignité comprenant l'administration desdits composés de platine modifiés et leur activation.
Bibliography:Application Number: WO2012IL50248