CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES

The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate co...

Full description

Saved in:
Bibliographic Details
Main Authors FEY, PETER, MAYER, AGATHE, CHRISTINE
Format Patent
LanguageEnglish
French
Published 06.12.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide. L'invention concerne un nouveau procédé énantiosélectif de préparation d'énantiomères S et R de N-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-5 méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. L'invention concerne également de nouveaux composés intermédiaires ainsi que leur utilisation dans la préparation des énantiomères S et R de N-{3,4-difluoro-2-[(2- fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
Bibliography:Application Number: WO2012EP59717