PROCESS FOR CONTINUOUS FLOW SYNTHESIS OF ß-????? CROTONATE

Beta aminocrotonates are important intermediates for the synthesis of Ca channel blockers. The processes available in the art are batch processes with yields about 85%. There are no continuous processes available for the synthesis of such compounds. This gap in the art is addressed by the invention...

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Bibliographic Details
Main Authors JOSHI, RAMESH, ANNA, KULKARNI, AMOL, ARVIND, JOSHI, ROHINI, RAMESH
Format Patent
LanguageEnglish
French
Published 20.12.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Beta aminocrotonates are important intermediates for the synthesis of Ca channel blockers. The processes available in the art are batch processes with yields about 85%. There are no continuous processes available for the synthesis of such compounds. This gap in the art is addressed by the invention by disclosing a continuous process resulting in high yields of beta amino crotonates. Les bêta amino crotonates constituent des intermédiaires importants pour la synthèses des inhibiteurs calciques. Les procédés selon l'état de la technique sont des procédés discontinus présentant des rendements d'environ 85%. Aucun procédé continu n'est disponible pour la synthèse de tels composés. Cette lacune est comblée par le procédé continu selon l'invention qui présente des rendements élevés en bêta amino crotonates.
Bibliography:Application Number: WO2012IN00302