SYNTHETIC OLIGOSACCHARIDES FOR STAPHYLOCOCCUS VACCINE

• Main Authors: CAMPBELL, A., STEWART, PLANTE, OBADIAH, J
• Format: Patent
• Language: English; French
• Published: 26.10.2012
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; FISHING; FORESTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRAPPING

The present invention synthetic oligo-ß-(1?6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-ß-(1?6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non- acetylated residues. The invention further provides antibodies to these synthetic oligo-ß-(1?6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-ß-(1?6)-glucosamines, such as Staphylococcus aureus. La présente invention concerne des structures synthétiques d'oligo-ß-(1,6)-glucosamine et un procédé qui permet essentiellement la synthèse de n'importe quel type d'oligo-ß-(1,6)-glucosamine présentant un nombre défini d'unités monosaccharide, y compris une configuration définie de résidus acétylés et non acétylés. L'invention concerne en outre des anticorps dirigés contre ces oligo-ß-(1,6)-glucosamines synthétiques ainsi que des compositions associées et des procédés de traitement et de prévention d'infections provoquées par les bactéries exprimant des poly-ß-(1,6)-glucosamines, telles que Staphylococcus aureus.