AMINOPYRIMIDINE KINASE INHIBITORS
Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CKl?), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFPß pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Us...
Saved in:
Main Authors | , , , , |
---|---|
Format | Patent |
Language | English French |
Published |
26.10.2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CKl?), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFPß pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CKl?), casein kinase 2 (CK2), Pim- 1, Pim-2, Pim-3, the TGFPß pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.
La présente invention concerne des composés, des compositions pharmaceutiques contenant ces composés, et des utilisations des composés et compositions en tant que modulateurs de caséine kinase 1 (par exemple, CKl?), caséine kinase 2 (CK2), Pim-1, Pim-2, Pim-3, la voie TGFPß, la voie Wnt, la voie JAK/STAT, et/ou la voie mTOR. La présente invention concerne en outre des utilisations pour le traitement ou la prévention d'une gamme d'indications thérapeutiques dues au moins en partie à une activité physiologique aberrante de caséine kinase 1 (par exemple, CKl?), caséine kinase 2 (CK2), Pim-1, Pim-2, Pim-3, la voie TGFPß, la voie Wnt, la voie JAK/STAT, et/ou la voie mTOR. |
---|---|
Bibliography: | Application Number: WO2012US34436 |