METHODS AND SYSTEMS USING PHARMACOKINETIC AND PHARMACODYNAMIC PROFILES IN INTERFERON-ALPHA THERAPEUTIC REGIMENS

• Main Authors: GROVENDER, ERIC A, VAN ANTWERP, WILLIAM P, LANDE, JEFFREY
• Format: Patent
• Language: English; French
• Published: 30.08.2012
• Subjects: CALCULATING; COMPUTING; COUNTING; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; ELECTRIC DIGITAL DATA PROCESSING; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Methodologies and systems relating to the delivery of interferon-a are provided. Analyses of clinical trial data show that observations of interferon-a pharmacokinetic profiles following its from delivery via a continuous infusion device can be correlated with viral responses to this therapeutic agent. Such information can be used, for example, to optimize the treatment of individuals infected with the hepatitis B and C viruses. L'invention porte sur des méthodologies et sur des systèmes concernant l'administration d'interféron-a. Des analyses de données d'essai clinique montrent que des observations de profils pharmacocinétiques d'interféron-a à la suite de son administration, par l'intermédiaire d'un dispositif de perfusion continue, peuvent être mises en corrélation avec les réponses virales à cet agent thérapeutique. De telles informations peuvent être utilisées, par exemple pour optimiser le traitement d'individus infectés par les virus de l'hépatite B et C.