PROCESS FOR OBTAINING COMPOUNDS DERIVED FROM TETRAHYDRO-ß-CARBOLINE
The invention relates to a process for obtaining compounds derived from tetrahydro-ß-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, foll...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
16.08.2012
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to a process for obtaining compounds derived from tetrahydro-ß-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.
L'invention porte sur un procédé pour l'obtention de composés dérivés de tétrahydro-ß-carboline, précisément de tadalafil et de produits intermédiaires provenant de sa synthèse, comprenant la réaction entre du pipéronal et un ester alkylique du D-tryptophane sous forme d'un sel, et en l'absence d'un quelconque autre constituant, suivie de l'halogénoacétylation et d'une cyclisation finale avec de la méthylamine. |
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Bibliography: | Application Number: WO2012EP52281 |