PROCESS FOR OBTAINING COMPOUNDS DERIVED FROM TETRAHYDRO-ß-CARBOLINE

The invention relates to a process for obtaining compounds derived from tetrahydro-ß-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, foll...

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Bibliographic Details
Main Authors BERZOSA RODRIGUEZ, XAVIER, MARQUILLAS OLONDRIZ, FRANCISCO
Format Patent
LanguageEnglish
French
Published 16.08.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for obtaining compounds derived from tetrahydro-ß-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine. L'invention porte sur un procédé pour l'obtention de composés dérivés de tétrahydro-ß-carboline, précisément de tadalafil et de produits intermédiaires provenant de sa synthèse, comprenant la réaction entre du pipéronal et un ester alkylique du D-tryptophane sous forme d'un sel, et en l'absence d'un quelconque autre constituant, suivie de l'halogénoacétylation et d'une cyclisation finale avec de la méthylamine.
Bibliography:Application Number: WO2012EP52281