ANTIBODY

[Problem] To provide an antibody to which a labeling substance or the like can be bound without deteriorating or losing an antigen-binding capability of the antibody. [Solution] An IgG antibody having the following characteristic properties: (1) some of disulfide bonds in the molecule are cleaved an...

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Bibliographic Details
Main Authors KOZAKI, SHINYA, SHINTANI, KOJI
Format Patent
LanguageEnglish
French
Japanese
Published 28.06.2012
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:[Problem] To provide an antibody to which a labeling substance or the like can be bound without deteriorating or losing an antigen-binding capability of the antibody. [Solution] An IgG antibody having the following characteristic properties: (1) some of disulfide bonds in the molecule are cleaved and reduced into thiol groups; (2) the molecular weight is not reduced by the cleavage of the disulfide bonds; and (3) the antigen-binding capability is retained. L'invention concerne un anticorps auquel une substance de marquage ou analogue peut être reliée sans détérioration ou perte d'une capacité de liaison à l'antigène de l'anticorps. L'invention concerne ainsi un anticorps IgG ayant les propriétés caractéristiques suivantes : (1) certaines des liaisons disulfure dans la molécule sont clivées et réduites en groupes thiol ; (2) le poids moléculaire n'est pas réduit par le clivage des liaisons disulfure ; et (3) la capacité de liaison à l'antigène est conservée.
Bibliography:Application Number: WO2011JP79799