LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES

This invention relates to compositions containing double- stranded ribonucleic acid (dsRNA) in a liquid particle formulation, methods of using the compositions to inhibit the expression of the Eg5/KSP and VEGF, and methods of using the compositions to treat pathological processes mediated by Eg5/KSP...

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Bibliographic Details
Main Authors GAMBA-VITALO, CHRISTINA, VAISHNAW, AKSHAY, SAH, DINAH, WEN-YEE, GOLLOB, JARED
Format Patent
LanguageEnglish
French
Published 18.05.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to compositions containing double- stranded ribonucleic acid (dsRNA) in a liquid particle formulation, methods of using the compositions to inhibit the expression of the Eg5/KSP and VEGF, and methods of using the compositions to treat pathological processes mediated by Eg5/KSP and VEGF expression, such as endometrial cancer. Cette invention concerne des compositions contenant des acides ribonucléiques à double brin (ARNds) dans une formulation de particules liquides, des procédés d'utilisation des compositions pour inhiber l'expression d'Eg5/KSP et de VEGF, et des procédés d'utilisations des compositions pour traiter des processus pathologiques à médiation par l'expression de Eg5/KSP et de VEGF, tels que le cancer de l'endomètre.
Bibliography:Application Number: WO2011US59937