COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA

There are provided compositions and methods for activating expression of an exogenous polynucleotide of interest only in the presence of a specific endogenous miRNA in a cell. Further provided are uses for the compositions in treatment and diagnosis of various conditions and disorders, for example b...

Full description

Saved in:
Bibliographic Details
Main Author ABITBOL, GUY
Format Patent
LanguageEnglish
French
Published 03.05.2012
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
Online AccessGet full text

Cover

More Information
Summary:There are provided compositions and methods for activating expression of an exogenous polynucleotide of interest only in the presence of a specific endogenous miRNA in a cell. Further provided are uses for the compositions in treatment and diagnosis of various conditions and disorders, for example by selectively activating expression of a toxin only in target cell populations. L'invention concerne des compositions et des procédés d'activation de l'expression d'un polynucléotide exogène d'intérêt, seulement en présence d'un miARN endogène spécifique dans une cellule. L'invention concerne en outre des utilisations des compositions dans le traitement et le diagnostic de divers états et troubles, par exemple par l'activation sélective de l'expression d'une toxine, seulement dans des populations cellulaires cibles.
Bibliography:Application Number: WO2010IL00894