MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES

The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salt...

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Main Authors TESTA, MARIA CATERINA, WAYKOLE, LILADHAR MURLIDHAR, LIU, HUI, KARPINSKI, PIOTR H, KAPA, PRASAD KOTESWARA, DE LA CRUZ, MARILYN, CALIENNI, JOHN VINCENT, GONG, BAOQING, MICHEL, PASCAL, FLUBACHER, DIETMAR, MOSE, RASMUS
Format Patent
LanguageEnglish
French
Published 05.04.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals. La présente invention a pour objet des procédés de fabrication d'un composé de formule 5 ou de l'un de stéréoisomères, tautomères ou sels, dans laquelle les substituants sont tels que définis dans le mémoire. L'invention a en outre pour objet de nouveaux procédés de fabrication de formes solides spécifiques du composé A et de ses sels, lesdites formes solides et l'utilisation desdites formes solides pour le traitement thérapeutique d'animaux à sang chaud.
Bibliography:Application Number: WO2011US53808