ANTIBODY-BASED CONSTRUCTS DIRECTED AGAINST TYROSINE KINASE RECEPTORS

• Main Authors: ROSS, BRIAN, L, WITTRUP, KARL, DANE, EPSTEIN, BENJAMIN, E, SPANGLER, JAMIE, B
• Format: Patent
• Language: English; French
• Published: 20.12.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention features antibody-based constructs that include a combination of two or more of a tetrameric antibody, a single chain antibody, a diabody, a triabody, another immunoglobulin-based moiety, as described herein, or biologically active variants thereof. L'invention concerne des constructions à base d'anticorps contenant une association d'au moins deux éléments compris parmi un anticorps tétramérique, un anticorps à chaîne unique, un anticorps dimérique, un anticorps trimérique, une autre fraction à base d'immunoglobuline, tels que présentés dans la description, ou de variants biologiquement actifs de ceux-ci.