ANTIBODIES THAT BIND MYOSTATIN, COMPOSITIONS AND METHODS

There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60. La présente invention concerne des antagonistes...

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Bibliographic Details
Main Authors ARORA, TARUNA, HAN, HQ, CHEN, QING, ZHOU, XIAOLAN, LU, HSIENG SEN
Format Patent
LanguageEnglish
French
Published 23.02.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60. La présente invention concerne des antagonistes sélectifs de la myostatine (y compris des anticorps), des acides nucléiques codant pour ces derniers et des procédés permettant de les fabriquer et de les utiliser. Anticorps neutralisants reconnaissant l'épitope conformationnel proche de la position 21 à 31 et de la position 50 à 60.
Bibliography:Application Number: WO2011US47806