ANAPLASTIC LYMPHOMA KINASE IN KIDNEY CANCER

• Main Authors: RIMKUNAS, VICTORIA, MCGUINNESS, SILVER, MATTHEW, REN, HAACK, HERBERT, CROSBY, KATHERINE, ELEANOR
• Format: Patent
• Language: English; French
• Published: 09.02.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The invention provides methods to identify, diagnose, and treat kidney cancer through the detection of expression and/or activity of anaplastic lymphoma kinase (ALK). The detection of the presence of a polypeptide with ALK kinase activity (e.g., by detecting expression and/or activity of the polypeptide), identify those kidney cancers that are likely to respond to an ALK-inhibiting therapeutic. La présente invention concerne des procédés destinés à identifier, diagnostiquer, et traiter le cancer du rein par le biais de la détection de l'expression et/ou de l'activité de la kinase des lymphomes anaplasiques (ALK). La détection de la présence d'un polypeptide doté d'une activité de kinase ALK (par exemple, par le biais de la détection de l'expression et/ou de l'activité du polypeptide), permet d'identifier les cancers du rein qui sont susceptibles de répondre à un agent thérapeutique inhibant la kinase ALK.