5-LIPOXYGENASE INHIBITORS

• Main Authors: GHORPADE, SATISH MADHAV, RAY, ABHIJIT, DAWANGE, MAHESH BALASAHEB, GUPTA, SUMAN, MALHOTRA, SANJAY, SRIVASTAVA, PUNIT, VERMA, ASHWANI KUMAR, DASTIDAR, SUNANDA GHOSH
• Format: Patent
• Language: English; French
• Published: 02.02.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to sulfonamides derivatives as 5-lipoxygenase (5-LO) inhibitors and a process for their synthesis. The present invention also relates to pharmacological compositions containing these sulfonamides derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, Type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders. La présente invention concerne des dérivés sulfonamides en tant qu'inhibiteurs de 5-lipoxygénase (5-LO) ainsi que leur procédé de synthèse. La présente invention concerne également des compositions pharmacologiques contenant ces dérivés sulfonamides, ainsi que des procédés de traitement de l'asthme bronchique, de la bronchopneumopathie chronique obstructive, de la polyarthrite rhumatoïde, de la sclérose en plaques, du diabète de type 1, du psoriasis, du rejet d'allogreffe, de la maladie inflammatoire de l'intestin, de la recto-colite hémorragique, de l'acné, de l'athérosclérose, du cancer, du prurit, de la rhinite allergique et d'autres troubles inflammatoires et/ou auto-immuns.