MANNOSE RECEPTOR C TYPE 1 (MRC1) CODON OPTIMIZED CELL LINE AND USES THEREOF

Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRCl) wherein the 5' region of the nucleotide sequence encoding MRCl is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody produ...

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Bibliographic Details
Main Authors MARTINI, PAOLO, STRACK-LOGUE, BETTINA, PAN, LUYING, SELLOS-MOURA, MARCIA, CONCINO, MICHAEL, F, RUIZ, JUAN, ALDERUCCI, SCOTT
Format Patent
LanguageEnglish
French
Published 26.01.2012
Subjects
HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA
HUMAN NECESSITIES
HYGIENE
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRCl) wherein the 5' region of the nucleotide sequence encoding MRCl is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody production, e.g., neutralizing antibody production, in a subject being treated for Gaucher disease using such cells. L'invention concerne des molécules d'acide nucléique isolées comprenant une séquence nucléotidique codant un récepteur de mannose de type C 1 (MRC1), dans lesquelles la région 5' de la séquence nucléotidique codant MRC1 est optimisée pour le codon, des cellules comprenant ces molécules d'acide nucléique, et des procédés de détection de la production d'anticorps, par exemple la production d'anticorps neutralisants, chez un sujet qui est traité pour la maladie de Gaucher au moyen de ces cellules.
Bibliography:Application Number: WO2011US44577