PHLOROGLUCINOL SYNTHASES AND METHODS OF MAKING AND USING THE SAME

The invention provides nucleic acids, amino acids, cells, and related methods for the biosynthetic production of phloroglucinol. In various embodiments, the invention includes an isolated or recombinant phloroglucinol synthase, which can be used in conjunction with an enzyme system for the biosynthe...

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Bibliographic Details
Main Authors JANCAUSKAS, JUSTAS, LAU, MAN KIT, BANOTAI, CRAIG, LEHNER, BETSY, FROST, JOHN
Format Patent
LanguageEnglish
French
Published 03.05.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMES
ENZYMOLOGY
EXPLOSIVES
EXPLOSIVES OR THERMIC COMPOSITIONS
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MANUFACTURE THEREOF
MATCHES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
USE OF SINGLE SUBSTANCES AS EXPLOSIVES
VINEGAR
WINE
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Summary:The invention provides nucleic acids, amino acids, cells, and related methods for the biosynthetic production of phloroglucinol. In various embodiments, the invention includes an isolated or recombinant phloroglucinol synthase, which can be used in conjunction with an enzyme system for the biosynthetic production of phloroglucinol, mono-O-methyl phloroglucinol, di-O-methyl phloroglucinol and tri-O-methyl phloroglucinol. The synthesis can be from a renewable carbon source. The phloroglucinol can be used in subsequent reactions. La présente invention concerne des acides nucléiques, des acides aminés, des cellules, et des procédés associés pour la production biosynthétique de phloroglucinol. Selon divers modes de réalisation, l'invention comprend une synthase isolée ou recombinante de phloroglucinol, qui peut être utilisée conjointement avec un système enzymatique pour la production biosynthétique de phloroglucinol, de mono-O-méthyl phloroglucinol, de di-O-méthyl phloroglucinol et de tri-O-méthyl phloroglucinol. La synthèse peut être réalisée à partir d'une source de carbone renouvelable. Le phloroglucinol peut être utilisé dans des réactions ultérieures.
Bibliography:Application Number: WO2011US42822