NOVEL EPRINOMECTIN INJECTABLE COMPOSITIONS
An improved injectable parasiticide composition for treating infections caused by ectoparasites and endoparasites, wherein the formulation comprises a solvent system comprising polyethylene glycol and optionally other excipients and a pharmaceutically acceptable solvent or mixture of solvents and co...
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Main Author | |
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Format | Patent |
Language | English French |
Published |
05.01.2012
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Subjects | |
Online Access | Get full text |
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Summary: | An improved injectable parasiticide composition for treating infections caused by ectoparasites and endoparasites, wherein the formulation comprises a solvent system comprising polyethylene glycol and optionally other excipients and a pharmaceutically acceptable solvent or mixture of solvents and co-solvents, said novel formulation being capable of improving the bioavailability and residence time of the parasiticide in the treated non human mammals. Preferred compositions according to the invention comprise parasiticides which are macrocyclic lactones having poor liphophilic properties, such as for example eprinomectin.
La présente invention concerne une composition parasiticide injectable pour le traitement d'infections provoquées par des ectoparasites et des endoparasites, la formulation comportant un système de solvant comprenant du polyéthylène glycol et éventuellement d'autres excipients et un solvant ou mélange de solvants et co-solvants pharmaceutiquement acceptable(s), ladite nouvelle formulation étant capable d'améliorer la biodisponibilité et le temps de séjour du parasiticide chez des mammifères non humains traités. Des compositions préférées selon l'invention comportent des parasiticides qui sont des lactones macrocycliques ayant de faibles propriétés lipophiles, telle que par exemple l'éprinomectine. |
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Bibliography: | Application Number: WO2011EP60969 |