PROTEASE VARIANTS OF HUMAN NEPRILYSIN

• Main Authors: BIRKENFELD, JORG, EICKER, ANDREA, FRESKGARD, PER-OLA, SCHEIDIG, ANDREAS, WOBST, NINA, JERMUTUS, LUTZ ULRICH JOCHEN WILHELM, WALLIN, JOHAN PER, GRUDZINSKA, JOANNA, STRERATH, MICHAEL, TEBBE, JAN, GOTZBERGER-SCHAD, CLAUDIA, HAUPTS, ULRICH, INNIG, JOSI, WEBSTER, CARL INNES, MAHLERT, CHRISTOPH
• Format: Patent
• Language: English; French
• Published: 29.12.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates to polypeptides comprising protease variants derived from human neprilysin having an increased specificity and/or activity against certain substrates, in particular against amyloid beta. La présente invention concerne des polypeptides comprenant des variantes de type protéase de la néprilysine humaine de type sauvage présentant une spécificité et/ou une activité altérées. En particulier, la présente invention concerne des polypeptides comprenant des variantes de type protéase dérivées de néprilysine humaine présentant une spécificité et/ou une activité améliorée contre certains substrats, en particulier contre le bêta-amyloïde.