ANTI-INFLAMMATORY AND QUORUM SENSING INHIBITION COMPOUNDS AND METHODS OF MAKING AND USING THEM

• Main Authors: SMITH, JENNIFER, VILLA, FRANCISCO, A, GERWICK, LENA, GERWICK, WILLIAM, H, ROWLEY, DAVID, C, CHOI, HUYKJAE
• Format: Patent
• Language: English; French
• Published: 19.04.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides novel compositions based on a structure designated as "Honaucin A", including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents. L'invention concerne de nouvelles compositions basées sur une structure désignée "honaucine A", y compris des variantes et des analogues de l'honaucine A, ainsi que des compositions pharmaceutiques, des liposomes et des nanoparticules comprenant ces compositions et des procédés de fabrication et d'utilisation de celles-ci. Dans une forme de réalisation, ces composés d'honaucine A et leurs variantes et analogues sont utilisés pour améliorer (y compris pour traiter et prévenir) l'inflammation. Dans une autre forme de réalisation, ces composés d'honaucine A et leurs variantes et analogues sont utilisés comme inhibiteurs de la détection du quorum bactérien. Dans d'autres formes de réalisation encore, les compositions de l'invention sont utilisées comme agents antibactériens.