COMPOSITIONS AND METHODS FOR PLASMA PEPTIDE ANALYSIS

The invention in some aspects provides composition, methods and kits for peptide analysis in blood by mass spectroscopy. In some aspects of the invention, isotopic peptides are provided that facilitate quantification of peptide levels, e.g., hepcidin levels, in blood by mass spectroscopy. Further as...

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Bibliographic Details
Main Authors ANDERSON, DAMON, SCOTT, STEEN, HANNO
Format Patent
LanguageEnglish
French
Published 01.12.2011
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention in some aspects provides composition, methods and kits for peptide analysis in blood by mass spectroscopy. In some aspects of the invention, isotopic peptides are provided that facilitate quantification of peptide levels, e.g., hepcidin levels, in blood by mass spectroscopy. Further aspects of the invention provide methods and compositions for quantifying blood hepcidin levels and evaluating iron-associated disorders. La présente invention concerne, dans certains aspects, une composition, des procédés et des kits pour analyse de peptides dans le sang par spectrométrie de masse. Certains aspects de l'invention concernent des peptides isotopiques qui facilitent la quantification des taux de peptide, par exemple, des taux d'hepcidine, dans le sang par spectrométrie de masse. D'autres aspects de l'invention concernent des procédés et des compositions pour quantifier les taux sanguins d'hepcidine et évaluer des troubles associés au fer.
Bibliography:Application Number: WO2011US37749