VESICLES WITH ENCAPSULATED SUBSTANCE AND PRODUCTION METHOD THEREFOR

• Main Authors: ANRAKU, YASUTAKA, KATAOKA, KAZUNORI, MIYATA, KANJIRO, CHUANOI, SAYAN, SUMA, TOMOYA, KISHIMURA, AKIHIRO, OBA, MAKOTO
• Format: Patent
• Language: English; French; Japanese
• Published: 24.11.2011
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING

Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces. L'invention concerne un procédé permettant de fabriquer facilement et efficacement des vésicules à substance encapsulée, une substance étant encapsulée dans la cavité de vésicules obtenues par auto-assemblage de polymères. Sont mélangés dans un milieu aqueux, avec la substance qui doit être encapsulée dans les espaces, des vésicules vides qui sont pourvues de membranes comprenant un premier polymère qui est un copolymère séquencé présentant des segments hydrophiles non chargés et un premier type de segments chargés et un second polymère présentant un second type de segments chargés qui portent une charge qui est l'opposée de celle dudit premier type de segments chargés ainsi que des espaces qui sont enserrés par lesdites membranes.