PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful f...

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Bibliographic Details
Main Authors MICHAELIDES, MICHAEL, FIX-STENZEL, SHANNON, JUDD, ANDREW
Format Patent
LanguageEnglish
French
Published 17.11.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora. La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables, A, B, R1, R2, R3, R4a, R5, et Z étant tels que définis dans la description. La présente invention concerne également des procédés de fabrication desdits composés, et des compositions contenant lesdits composés qui sont utiles pour l'inhibition de kinases telles qu'aurora.
Bibliography:Application Number: WO2011US36298