NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS

Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome;...

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Main Authors HALE, JEFFREY, J, SHEN, DONG-MING, WU, ZHICAI, SHI, ZHI-CAI, YANG, CANGMING, JIANG, JINLONG, SHU, MIN
Format Patent
LanguageEnglish
French
Published 17.11.2011
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders. La présente invention concerne des composés de formule développée I qui sont des inhibiteurs de la prolylcarboxypeptidase (PrCP). Les composés de la présente invention peuvent être utilisés en vue de la prévention et du traitement d'affections associées à l'activité enzymatique de la PrCP, telles que les anomalies du métabolisme et notamment l'obésité, le diabète, le syndrome métabolique, les troubles associés à l'obésité et les troubles associés au diabète.
Bibliography:Application Number: WO2011US35501