ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION

• Main Authors: TOM-YEW, STACEY A. L, ESCOBAR-CABRERA, ERIC, LARIO, PAULA, I, D'ANGELO, IGOR, OHRN, ANDERS, BLEILE, DUSTIN, POON, DAVID K. Y, DIXIT, SURJIT B
• Format: Patent
• Language: English; French
• Published: 24.11.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Rationally designed antibodies and polypeptides that comprise two Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides comprise Fc region mutations at two positions that synergistically make the polypeptides more effective when incorporated in antibody therapeutics than those having wild-type Fc components. L'invention concerne des anticorps et des polypeptides conçus de façon rationnelle et contenant deux substitutions d'acides aminés de région Fc qui confèrent de façon synergétique une sélectivité et une affinité de liaison accrues à un récepteur Fc cible. Les polypeptides contiennent des mutations de région Fc à deux emplacements, ce qui rend de façon synergétique ces polypeptides plus efficaces que les polypeptides contenant des composants Fc de type sauvage, lorsqu'ils sont incorporés dans des agents thérapeutiques à base d'anticorps.