A SUBSTITUTED PYRIMIDINE AS A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST

The present invention is directed to a 2,6-substituted-4-monosubstitutedamino-pyrinudine compound of formula (I) as set forth herein, or an enantiomer thereof, or an ester prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention...

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Bibliographic Details
Main Authors STOKLOSA, GREGORY T, AGUIAR, JOACY C, SHUM, PATRICK WAI-KWOK, POLI, GREGORY B, ZHAO, ZHICHENG, HARRIS, KEITH JOHN, CHOI-SLEDESKI, YONG-MI, REILING, STEPHAN
Format Patent
LanguageEnglish
French
Published 22.09.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to a 2,6-substituted-4-monosubstitutedamino-pyrinudine compound of formula (I) as set forth herein, or an enantiomer thereof, or an ester prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. La présente invention concerne un composé amino-pyrimidine substitué en positions 2 et 6 et monosubstitué en position 4 de formule (I) tel que décrit ici, ou un énantiomère de celui-ci, ou un promédicament ester ou un sel pharmaceutiquement acceptable de celui-ci, ou une composition pharmaceutique comprenant un tel composé. L'invention concerne également un procédé de traitement d'un patient par le biais de l'administration d'une quantité pharmaceutiquement efficace d'un tel composé.
Bibliography:Application Number: WO2011US28433