DIHYDROPTERIDINONE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF

Dihydropteridinone derivatives, preparation method and pharmaceutical use thereof are disclosed. Specifically, disclosed are new dihydropteridinone derivatives represented by general formula (I), their preparation method, pharmaceutical compositions comprising said derivatives and their use as thera...

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Main Authors ZENG, XIANGQUAN, ZHANG, NONG, DONG, ZHENG, TANG, PENG CHO, SHU, SIJIE, LIU, LUNJUN
Format Patent
LanguageChinese
English
French
Published 22.09.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Dihydropteridinone derivatives, preparation method and pharmaceutical use thereof are disclosed. Specifically, disclosed are new dihydropteridinone derivatives represented by general formula (I), their preparation method, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors ,wherein each substituent of the general formula (I) is defined as in the specification La présente invention concerne des dérivés de dihydroptéridinone, leur procédé de préparation et leur utilisation pharmaceutique. La présente invention concerne spécifiquement de nouveaux dérivés de dihydroptéridinone représentés par la formule générale (I), leur procédé de préparation, des compositions pharmaceutiques comprenant lesdits dérivés et leur utilisation en tant qu'agents thérapeutiques, notamment des inhibiteurs de la kinase PLK, chaque substituant de formule générale (I) ayant la définition proposée dans la description.
Bibliography:Application Number: WO2011CN00062