ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING

• Main Authors: PONS, JAUME, SHELTON, DAVID, LOUIS, CHABOT, JEFFREY, RAYMOND, METTETAL II, JEROME, THOMAS, LIANG, HONG, RAJPAL, ARVIND, MAYAWALA, KAPIL, CHAPARRO RIGGERS, JAVIER, FERNANDO, GOMES, BRUCE, CHARLES
• Format: Patent
• Language: English; French
• Published: 15.09.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the KD or koff ratio at pH 5.5/ pH 7.4 or at pH 6.0/ pH 7.4 is mor...