CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS
The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercho...
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Main Authors | , , , , , , , , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
10.11.2011
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
La présente invention concerne des polymères réticulés d'amine et d'amide efficaces pour la liaison et l'élimination des sels biliaires du tractus gastro-intestinal. Ces polymères liant l'acide biliaire ou les compositions pharmaceutiques de ceux-ci peuvent être administrés aux sujets pour traiter diverses pathologies, incluant l'hypercholestérolémie, le diabète, le prurit, le syndrome-diarrhée du côlon irritable (IBS-D), la malabsorption de l'acide biliaire et d'autres. |
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Bibliography: | Application Number: WO2011US26099 |