ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN

The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compos...

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Main Authors ZHENG, XIAO, MEI, NGUYEN, HANH, NHO, BUCHANAN, JOHN, L, DU, BINGFAN, BREGMAN, HOWARD, CHAKKA, NAGASREE, DIMAURO, ERIN, F
Format Patent
LanguageEnglish
French
Published 25.08.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. La présente invention concerne des composés qui sont des inhibiteurs de canaux sodiques sensibles au voltage (Nav), en particulier Nav 1.7, et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par l'inhibition de ces canaux, en particulier, des troubles de douleur chronique. La présente invention concerne en outre des compositions pharmaceutiques contenant de tels composés et des procédés pour préparer de tels composés.
Bibliography:Application Number: WO2011US25092