PHENYL-HETEROARYL DERIVATIVES AND METHODS OF USE THEREOF

• Main Authors: SUNDERMANN, KURT, RAO, MOHAN, GUPTA, SUPARNA, JONES, DAVID, BANNER, WILLIAM, KENNETH, BONDLELA, MURALIDHAR, WANG, PINGZHEN, HARI, ANITHA, QABAJA, GHASSAN, GOHIMUKKULA, DEVI, REDDY, GOWDA, RAJU, BORE, ZHU, JEFF, JIQUN, ANDREWS, ROBERT, C, COOPER, JEREMY, T
• Format: Patent
• Language: English; French
• Published: 25.08.2011
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases. La présente invention concerne des dérivés de phényl-hétéroaryle de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont utiles dans le traitement de maladies médiées par RAGE telles que la maladie d'Alzheimer. La présente invention concerne en outre des procédés pour la préparation de composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et/ou compositions pharmaceutiques dans le traitement de maladies médiées par RAGE.