PREPARATION OF LAMIVUDINE FORM I

• Main Authors: COHEN, BENJAMIN, WAHL, CHRISTOPHER, ARROYO, ITZIA, Z, COTE, AARON S
• Format: Patent
• Language: English; French
• Published: 18.08.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A thermodynamically controlled process for preparing Form I polymorph of lamivudine is described, wherein the process involves crystallizing Form I at a temperature of from about 00C to about 500C from a mixture which comprises (a) lamivudine or an acid salt thereof or both, (b) a solvent system com...