1,4-QUINONES AND THEIR SULFUR ANALOGUES USEFUL AS LIGANDS OF N-ACETYLTRANSFERASES

The invention provides 1,4-quinones, 1,4-naphthoquinones and their sulphur analogues as inhibitors of hNAT1, an enzyme which is both a diagnostic marker and drug target for breast cancer. Some of the compounds of the invention are also chromogenic in the presence of hNAT1. The compounds of the inven...

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Main Authors LAURIERI, NICOLA, SIM, EDITH, WESTWOOD, ISAAC, MARK, DAVIES, STEPHEN, GRAHAM, CRAWFORD, MATTHEW, HOWARD, JAMES, RUSSELL, ANGELA, JANE, KAWAMURA, AKANE
Format Patent
LanguageEnglish
French
Published 11.08.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides 1,4-quinones, 1,4-naphthoquinones and their sulphur analogues as inhibitors of hNAT1, an enzyme which is both a diagnostic marker and drug target for breast cancer. Some of the compounds of the invention are also chromogenic in the presence of hNAT1. The compounds of the invention are used for detecting for and/or measuring hNAT1 and for inhibiting hNAT1 in the treatment of disease. L'invention concerne des 1,4-quinones, des 1,4-naphtoquinones et leurs analogues soufrés en tant qu'inhibiteurs de hNAT1, une enzyme qui est à la fois un marqueur diagnostique et une cible de médicament pour le cancer du sein. Certains des composés de l'invention sont également chromogènes en présence de hNAT1. Les composés de l'invention sont utilisés pour détecter et/ou pour mesurer hNAT1 et pour inhiber hNAT1 dans le traitement de maladies.
Bibliography:Application Number: WO2010GB51840