ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such...

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Main Authors LINSELL, MARTIN, SHERINGHAM, HILDEBRANDT, DARIN, JAMES, AGGEN, JAMES, BRADLEY, GOLDBLUM, ADAM, AARON, GLIEDT, MICAH, JAMES, KANE, TIMOTHY, ROBERT, DOZZO, PAOLA
Format Patent
LanguageEnglish
French
Published 19.04.2012
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. L'invention concerne des composés antibactériens de structure (I), y compris leurs stéréoisomères, sels pharmaceutiquement acceptables et promédicaments, dans laquelle Q1, Q2, Q5, R1, R2, R3, Z1 et Z2 sont tels que définis dans le présent document. Des procédés associés avec la préparation et l'utilisation de tels composés, ainsi que des compositions pharmaceutiques comprenant de tels composés, sont également décrits.
Bibliography:Application Number: WO2010US52043