UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES

• Main Authors: KIRK, PETER, B, HOKANSON, CRAIG, A, CREA, ROBERTO, LISTON, DAVID, R, CAPPUCCILLI, GUIDO, SHEN, RANDY
• Format: Patent
• Language: English; French
• Published: 12.05.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or AxI proteins. L'invention porte sur des bibliothèques polypeptidiques de fibronectine de type III (FN3), ainsi que sur leur utilisation dans l'identification de peptides de liaison de type fibronectine ayant des affinités de liaison élevées, par exemple supérieures à 300 nM, pour les protéines VEGFR2 ou AxI.