UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES

Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or AxI proteins. L'invention porte sur des bibliothèques polypeptidiques de fibronectine de...

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Main Authors KIRK, PETER, B, HOKANSON, CRAIG, A, CREA, ROBERTO, LISTON, DAVID, R, CAPPUCCILLI, GUIDO, SHEN, RANDY
Format Patent
LanguageEnglish
French
Published 12.05.2011
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMBINATORIAL CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or AxI proteins. L'invention porte sur des bibliothèques polypeptidiques de fibronectine de type III (FN3), ainsi que sur leur utilisation dans l'identification de peptides de liaison de type fibronectine ayant des affinités de liaison élevées, par exemple supérieures à 300 nM, pour les protéines VEGFR2 ou AxI.
Bibliography:Application Number: WO2010US49391