4- (PYRIMIDIN-2-YL) -PIPERAZINE AND 4- (PYRIMIDIN-2-YL) -PIPERIDINE DERIVATIVES AS GPR119 MODULATORS

A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as GPR119 modulators, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, and pharmaceutical compositions containing them. L'...

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Main Authors DE LA MOTTE, HANNA, O'DONNELL, CHARLES, JOHN, BIRCH, ALAN, MARTIN, BUTLIN, ROGER, JOHN, LEACH, ANDREW, CLARKE, DAVID, STEPHEN, MACFAUL, PHILIP, ALEXANDER, SCOTT, JAMES, STEWART, WHITTAMORE, PAUL, ROBERT, OWEN, BROO, DAN, ANDERS, DAVIDSSON, OJVIND, PERCY, JOHANSSON, KJELL, ERIK
Format Patent
LanguageEnglish
French
Published 17.03.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as GPR119 modulators, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, and pharmaceutical compositions containing them. L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, des procédés de préparation de ces composés, leur utilisation en tant que modulateurs du GPR119, des méthodes d'utilisation thérapeutique de ces composés, en particulier dans le traitement de l'obésité et du diabète sucré, ainsi que des compositions pharmaceutiques les contenant.
Bibliography:Application Number: WO2010GB51483