PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY

The present invention relates to the GPR119 agonist, N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-methyl-6-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)pyrimidin-4-amine (Compound 1, Formula (I)), and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful in the treatment of GPR...

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Bibliographic Details
Main Authors JONES, ROBERT M, LEHMANN, JUERG
Format Patent
LanguageEnglish
French
Published 13.01.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to the GPR119 agonist, N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-methyl-6-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)pyrimidin-4-amine (Compound 1, Formula (I)), and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful in the treatment of GPR119-related disorders, such as, metabolic-related disorders and complications thereof, such as, diabetes and obesity. La présente invention porte sur l'agoniste du GPR119, la N-(2-fluoro-4-(méthylsulfonyl)phényl)-5-méthyl-6-(1-(5-méthylpyrazin-2-yl)pipéridin-4-yloxy)pyrimidin-4-amine (Composé 1, Formule (I)) et sur ses sels solvates et hydrates pharmaceutiquement acceptables, qui sont utiles dans le traitement de troubles associés à GPR119, tels que les troubles liés au métabolisme et leurs complications, comme le diabète et l'obésité.
Bibliography:Application Number: WO2010US41325