PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

• Main Authors: SHEPPARD, GEORGE, S, FIDANZE, STEVE, D, MANTEI, ROBERT, A, BELL, RANDY, L, WANG, GARY, T, SORENSEN, BRYAN, K, BA-MAUNG, NWE, Y, ERICKSON, SCOTT, A, CLARK, RICHARD, F, WANG, JIEYI
• Format: Patent
• Language: English; French
• Published: 02.12.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR. La présente invention porte sur des composés de formule (I) ou sur des sels ou solvates pharmaceutiquement acceptables de ceux-ci, formule dans laquelle G1, R2, R3, R4, n, p, Ar1 et Ar2 sont tels que définis dans la description. La présente invention porte également sur des procédés de fabrication desdits composés, et sur des compositions comprenant lesdits composés qui sont utiles pour inhiber des kinases telles que IGF-IR.