PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such a...

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Main Authors SHEPPARD, GEORGE, S, FIDANZE, STEVE, D, MANTEI, ROBERT, A, BELL, RANDY, L, WANG, GARY, T, SORENSEN, BRYAN, K, BA-MAUNG, NWE, Y, ERICKSON, SCOTT, A, CLARK, RICHARD, F, WANG, JIEYI
Format Patent
LanguageEnglish
French
Published 02.12.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR are also disclosed. L'invention porte sur des composés de formule (I) ou sur des sels ou solvates pharmaceutiquement acceptables de ceux-ci, formule dans laquelle G1, L1, R2, R3, n, p, Ar1 et Ar2 sont tels que définis dans la description. L'invention porte également sur des procédés de fabrication desdits composés, et sur des compositions comprenant lesdits composés qui sont utiles pour inhiber des kinases telles que IGF-IR.
Bibliography:Application Number: WO2010US36184