N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula (I): which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer. La présente invent...

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Main Authors SHEPARD, STACEY, ARVANITIS, ARGYRIOS, G, WANG, HAISHENG, SHAO, LIXIN, FOLMER, BEVERLY, ZHU, WENYU, STORACE, LOUIS, RODGERS, JAMES, D, GLENN, JOSEPH P
Format Patent
LanguageEnglish
French
Published 25.11.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula (I): which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer. La présente invention concerne des dérivés N-(hétéro)aryl-pyrrolidine de formule (I) : qui sont des inhibiteurs JAK, tels que des inhibiteurs JAK1 sélectifs. Ces inhibiteurs sont utiles dans le traitement de maladies associées à la JAK, comprenant par exemple les affections inflammatoires et les maladies auto-immunes, ainsi que le cancer.
Bibliography:Application Number: WO2010US35783