ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY

• Main Authors: CASSON, DUNCAN, MAGINN, MARK, POWELL, JOHN
• Format: Patent
• Language: English; French
• Published: 11.11.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. Cette invention concerne des anticorps anti-facteur de croissance nerveux (nGF) contenant une région constante IgG4 comprenant une mutation stabilisante d'une région charnière, lesdits anticorps présentant une demi-vie sérique chez le singe cynomolgus incroyablement longue. L'invention concerne également des compositions pharmaceutiques comprenant ces anti-anticorps anti-nGF, les acides nucléiques codant ces anticorps anti-nGF, des cellules hôtes exprimant ces anticorps anti-nGF et des méthodes d'utilisation des anticorps pour traiter des maladies ou des pathologies associées au nGF.