FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula (I) are presented: (I). wherein Q is a portion of a polymethine bridge selected from the group consisting of: (a) and (b). Also included are bioconjugates...

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Bibliographic Details
Main Authors DRANEY, DANIEL R, XU, XINSHE
Format Patent
LanguageEnglish
French
Published 23.12.2010
Subjects
ADHESIVES
CHEMISTRY
DYES
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LAKES
MEASURING
METALLURGY
MISCELLANEOUS APPLICATIONS OF MATERIALS
MISCELLANEOUS COMPOSITIONS
MORDANTS
NATURAL RESINS
ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES
PAINTS
PHYSICS
POLISHES
TESTING
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Summary:Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula (I) are presented: (I). wherein Q is a portion of a polymethine bridge selected from the group consisting of: (a) and (b). Also included are bioconjugates of the compounds of Formula (I), methods of labeling biomolecules with the compounds, and methods of imaging. La présente invention concerne des composés et des procédés qui sont utiles pour l'imagerie non invasive dans la gamme spectrale de l'infrarouge proche. Les composés de cyanine de formule (I) sont présentés : (I) dans laquelle Q est une partie d'un pont polyméthine choisie dans le groupe constitué de : (a) et (b). La présente invention concerne en outre des bioconjugués des composés de formule (I), des procédés de marquage de biomolécules avec les composés, et des procédés d'imagerie.
Bibliography:Application Number: WO2010US31434